Recently, Wang Jiajia, as the first author,tookHenanUniversity as the first unit,published the article on theFrontiers in Chemistrynamed“Facile and stereo-selective synthesis of UDP-D-α-xylose and UDP-L-β-arabinose using UDP-sugar pyrophosphorylase”. The impact factor of the magazine is 3.99, the partition table of JCR is the second sector of chemistry. The glycosyl donors of UDP-D-α-xylose and UDP-L-β-arabinose can be connected to a specific substrate structure by the corresponding transferase（glycosyltransferase，GT）, which has important biological significance in animals and plants. Such as the glycosylation of Xylose, which is essential in the activation of the signal path of the Notch signaling receptor, and the Arabinose chain structure, which plays an important part in expression of antibodies in plants. However, there’s no convenient and effective way to produce this kind of glycosyl donors. The way to produce UDP-sugar in the research is shown as below. Take free-sugar Xylose and Arabinose as the starting material, and add the P-methyl phenylsulfonyl hydrazine to the first position of the sugar ring structure, and then add the phosphate group to the first position of the compound under the condition with CuCl2and H3PO4,and then we get theα/βmixture. Using the substrate specificity of the AtUSP, the D-α-Xylose-1-P and L-β-Arabinose-1-P can be selectively identified, and after the purification, homologous UDP-sugar can be produced. In the research, a effective way to produce glycosyl donors, combing with the chemoenzymatic method, has been found, which is dispensed with saccharide protection group with only three steps of reactions and simple purification, that provides powerful guarantee to have deeper research in glycobiology of Xylose and Arabinose.

Wang Jiajia, graduating from the School of Pharmacy in Nankai University, was the student of Professor Zhao wei and Professor Wang Peng when he was in university. He took Carbohydrate Chemistry and Chemo biology as his major research field later. During his PhD study, Mr. Wang’s chief study was on the synthesis of small-molecule probe and its application in cell’s target of rapamycin. By introducing genes like nitrine and alkynyl into natural product and molecular carbohydrates, the interest protein was accumulated and separated, and the gene and protein militated with each other. Mr. Wang lucubrated the function in this reaction and gained promising progress in this field. Wang Jiajia joined Li Xia’s team of the School of Medical Sciences in Henan University in July, 2017. This team mainly researched on innate immunity reaction’s epigenetic regulation and glycometabolism’s role in infectious diseases’regulatory mechanism, hoping to obtain O-GlcNAc, a protein that was involved in immunity infection, through molecular probe and other technology and deeply exploring its further functions in human’s development.